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韩飞
作者: 发布时间: 2022-06-09 16:09 浏览次数:

姓名:韩飞

学历:博士

职称:教授

导师类别:博士、硕士研究生导师

研究方向和领域:环境污染物与生殖损伤、肿瘤发病的机制及防治研究

Emailflyskyhf@cqmu.edu.cn /han16897723@163.com

韩飞,重庆医科大学特聘教授、高层次引进人才和未来医学青年创新团队团长;重庆市优秀博士学位论文获得者,军队高端优秀专业技术人才津贴获得者;曾受邀赴日本国立基础生物学研究所交流学习;中国毒理学会,中华预防医学会和中国抗癌协会三个国家一级学会专业委员会委员;荣立个人三等功1次,陆军军医大学优秀人才重点扶持对象,陆军军医大学优秀博士学位论文获得者。近5年,主持国家、省部级等课题共计10项,在Aging CellEBioMedicineOncogeneBiochim Biophys Acta Rev CancerJ Exp Clin Cancer ResCell Death DifferMol Ther-Nucl AcidsHum Reprod等国际知名杂志发表SCI论文50余篇,其中以第一或通讯作者发表SCI论文20余篇;授权/理国家发明专利6项,其中第一发明人3项,第二发明人2项。应邀担任British Journal of Pharmacology,Molecular Therapy,International Journal of Biological Macromolecules,Briefings in Bioinformatics,MedComm,View等个10多国际SCI杂志编辑和/或评审专家。

主持的代表性项目

1. 国家自然科学基金面上项目,早期诊断候选分子SCGB3A1在肺鳞癌转移中发挥特异性

作用的机制研究(82372745),49万元,2024/01-2027/12,主持,在研;

2. 国家自然科学基金面上项目,SOX30在肺腺癌和肺鳞癌形成不同选择剪切蛋白的特异性定位、作用和机制研究(82073137),66万元,2021/01-2024/12,主持,在研;

3. 重庆市自然科学基金面上项目,新抑癌基因SOX30在晚期卵巢癌预后评估和化疗治疗中的作用及机制研究(cstc2020jcyj-msxmX0419),10万元,2020/07-2023/06,主持,在研;

4.重庆医科大学未来医学青年创新项目,肺癌分子筛查、早期诊断和精准治疗研究(W0151),50万元,2022/12-2025/12,主持,在研;

5.重庆医科大学科研启动项目,环境污染物损伤效应的机制及防治研究(R4022),80万元,2022/02-2030/02,主持,在研

6. 科技创新能力提升专项-前沿探索项目,SOX30在非梗阻性无精症疾病中的作用和机制研究(2019XQY02),30万元,2020/01-2021/12,主持,已结题;

7. 国家自然科学青年基金项目,SOX30抑制非小细胞肺癌转移的机制研究(81502551),21.6万元,2016/01-2018/12,主持,已结题;

8. 第三军医大学优秀人才库基金项目,SOX30在肺癌发病和雄性生殖异常中的作用和分子机制研究(2016609),20万元,2017/01-2019/12,主持,已结题;

9. 云南省应用基础研究项目,LHX6基因抑制肺癌转移的机制研究(2017FE468-094),10万元,2017/07-2020/06,主持,已结题;

代表性第一或通讯作者论文:

1. Lu C, Liang Y, Cheng Y, Peng C, Sun Y, Liu K, Li Y, Lou Y, Jiang X, Zhang A, Liu J, Cao J,Han F. Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling.Food Chem Toxicol. 2023; 179:113970. (通讯作者)

2. Li Y, Zhang Z, Wang J, Liu C, Liu Y, Jiang X, Chen Q, Ao L, Cao J, Sun L,Han F, Liu J. Effects and possible mechanisms of combined exposure to noise and carbon monoxide on male reproductive system in rats. Environ Toxicol. 2023. doi:10.1002/tox.23927.Online ahead of print. (通讯作者)

3.Gao P, Sun N, Zhao T, Sun Y, Gu J, Ma D, Tian H, Peng Z, Zhang Y,Han F. Identification of prognostic indicators, diagnostic markers, and possible therapeutic targets among LIM homeobox transcription factors in breast cancer. Cancer Innovation. 2022, 1:252-69. (通讯作者)

4.Han F, Yin L, Jiang X, Zhang X, Zhang N, Yang J, Ouyang W, Hao X, Liu W, Huang Y, Chen H, Gao F, Li Z, Guo Q, Cao J,Liu J. Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation.Aging Cell. 2021; 20:e13343. (第一作者)

5. Gao PP, Qi XW, Sun N, Sun YY, Zhang Y, Tan XN, Ding J,Han F.The emerging roles of dual-specificity phosphatases and their specific characteristics in human cancer.Biochim Biophys Acta Rev Cancer.2021, 1876: 188562.(通讯作者)

6. Sun N, Gao P, Li Y, Yan Z, Peng Z, Zhang Y,Han F, Qi X. Screening and identification of key common and specific genes and their prognostic roles in different molecular subtypes of breast cancer.Front Mol Biosci. 2021, 8:619110. (通讯作者)

7.Han F, Jiang X, Li Z, Zhuang X, Zhang X, Ouyang W, Liu W, Mao C, Chen Q, Huang C, Gao F, Cui Z, Ao L, Li Y, Cao J, Liu J. Epigenetic inactivation of SOX30 is associated with male infertility and offers a therapy target for non-obstructive azoospermia.Mol Ther Nucleic Acids.2020,19: 72-83. (第一作者)

8.Hao X, Gao L, Zhang N, Chen H, Jiang X, Liu W, Ao L, Cao J,Han F, Liu J. Tac2-N acts as a novel oncogene and promotes tumor metastasis via activation of NF-κB signaling in lung cancer.J Exp Clin Cancer Res.2020, 38:319. (通讯作者)

9.Han F, Liu W, Li J, Zhang M, Yang J, Zhang X, Hao X, Yin L, Mao C, Jiang X, Cao J, Liu J. SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer.Endocr Relat Cancer. 2019; 26:303–19.(第一作者)

10.Han F, Liu WB, Shi XY, Yang JT, Zhang X, Li ZM, Jiang X, Yin L, Li JJ, Huang CS, Cao J, Liu JY.SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcript- ional and Posttranslational Regulation of β-Catenin in Lung Cancer.EBioMedicine.2018; 31: 253-66. (第一作者)

11.Han F, Zhang M, Liu W, Sun L, Hao X, Yin L, Jiang X, Cao Jia, Liu J. SOX30 specially prevents Wnt-signaling to suppress metastasis and improve prognosis of lung adenocarcinoma patients.Respir Res. 2018; 19:241. (第一作者)

12. Yang J,Han F, Liu W, Chen H, Hao X, Jiang X, Yin L, Huang Y, Cao J, Zhang H, Liu J. ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway.J Exp Clin Cancer Res.2017, 36:170. (共同第一)

13.Han F, Liu W, Jiang X, Shi X, Yin L, Ao L, Cui Z, Li Y, Huang C, Cao J, Liu J. SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer.Oncogene.2015; 34: 4391-402. (第一作者)

14.Han F, Liu W, Xiao H, Dong Y, Sun L, Mao C, Yin L, Jiang X, Ao L, Cui Z, Cao J, Liu J. High expression of SOX30 is associated with favorable survival in human lung adenocarcinoma.Sci Rep. 2015; 5:13630. (第一作者)

15. Liu WB,Han F, Du XH, Jiang X, Li YH, Liu Y, Chen HQ, Ao L, Cui ZH, Cao J, Liu JY. Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer.Int J Cancer. 2015,134:1311-22. (共同第一)

主要发明专利情况:

1.韩飞,刘晋祎,曹佳,等。基因SOX30在治疗非阻塞性无精症中的应用。国家发明专利。专利号:ZL 201910897282.2(第一发明人)

2.韩飞,刘晋祎,曹佳,等。一种用于非阻塞性无精症的诊断盒。国家发明专利。专利号:ZL 201910897201.9(第一发明人)

3.韩飞,刘晋祎,刘文斌,等。Sox30敲除和可恢复型小鼠动物模型构建方法及应用。国家发明专利。专利号:ZL 201910897179.8(第一发明人)

4. 张明谦,韩飞,李艳,等。Sox30基因在卵巢癌发展及治疗中的应用。国家发明专利。专利号:ZL 201908697031.8(第二发明人)

5. 刘文斌,韩飞,陈洪强,等。一种肿瘤检测物及其制备方法与应用。国家发明专利。专利号:CN 109541215A(第二发明人)

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