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丁裕斌
作者: 发布时间: 2022-10-29 16:20 浏览次数:

丁裕斌 博士 教授 博士生导师

教育部生殖与发育国际合作联合实验室·公共卫生学院

重庆市渝中区医学院路1号 97邮箱 400016

电话:02368485008

邮箱:dingyb@cqmu.edu.cndingyb@gmail.com

个人简介

重庆医科大学特聘教授/博士生导师,生殖与发育教育部国际合作联合实验室PI,香港大学郑裕彤博士奖学金获得者、匹兹堡大学博士后(国家留学基金委公派资助),入选重庆市“高校中青年骨干教师”和“留学人员回国创业创新支持计划”等人才支持项目资助。系NSFC、英国研究理事会(RCUK)评审专家,中国生理学会生殖科学专委会常务理事,重庆市免疫学会会员和重庆市遗传学学会会员。

先后承担了5项国家自然科学基金、1项科技部重点研发计划(2018YFC1004401骨干)、4项市自然科学基金;以通讯/共同通讯/第一作者身份在Nucleic Acids Research(ESI高被引论文)、Human Reproduction等高水平学术期刊上发表成果50余项;指导本科生获国家级创新论坛/设计大赛一等奖和二等奖各1项;近2年来带领团队获得NSFC等国家级项目6项。

主要从事女性生殖与胚胎发育的生物学基础、流行病学、临床预测模型与转化技术开发等研究。成功建成了成渝地区辅助生殖人口和子代的大型队列(CYART)与生物样本库、临床诊疗大数据库以及相关分析技术平台;成功建立了微量组织建库测序技术、iPSC/干细胞诱导体外模型、全基因组功能基因筛选、基因编辑小鼠疾病模型等技术开展相关疾病的发病机制研究。

学习与工作经历:

2018.10~ 教授,重庆医科大学公共卫生学院/

生殖与发育教育部国际合作联合实验室

2015.03~2017.03 博士后,美国匹兹堡大学医学院(国家CSC公派)

2014.07~2015.03 Research fellow,香港大学李嘉诚医学院(郑裕彤博士奖学金资助)

2005.07~2018.09 助教,讲师,副教授,重庆医科大学公共卫生学院

2008.09~2011.06 重庆医科大学/Mälardalen University,临床检验诊断学,博士

1998.09~2005.06 西南大学,细胞生物学/植物保护,硕士/学士

代表性研究论文(*示通讯作者)

第一作者/通讯作者发表论文

1.Ming-Xing Chen#, Xiang-Qian Meng#, Zhao-Hui Zhong, Xiao-Jun Tang, Tian Li, Qian Feng, Enoch Appiah Adu-Gyamfi, Yan Jia, Xing-Yu Lv, Li-Hong Geng, Lin Zhu, Wei He*, Qi Wan*,Yu-Bin Ding*. An Individualized Recommendation for Controlled Ovary Stimulation Protocol in Women who are exposed to the GnRH Agonist Long-acting protocol or the GnRH Antagonist Protocol: a Retrospective Cohort Study. Frontiers in Endocrinology. 2022.doi: 10.3389/fendo.2022.899000 (IF2021=6.055)

2. Zhuo-Hang Li, Xia Li, Fang-Fang Li, Zhi-Hong Wu, You-Long Xie, Shuang Zhang, Xue-Mei Chen, Ying-Xiong Wang*,Yu-Bin Ding*, Tai-Hang Liu*. The roles of ADAMDEC1 in trophoblast differentiation during normal pregnancy and preeclampsia. Mol Hum Reprod. 2022 Apr 29;28(5):gaac014. (IF2021=4.518)

3. Lidan Wang#, Wei Zhang#, Xianglu Wu#, Xiao Liang, Lijie Cao, Jincheng Zhai, Yiyang Yang, Qiuxiao Chen, Hongqing Liu, Jun Zhang,Yubin Ding*, Feng Zhu*, Jing Tang*. MIAOME: Human Microbiome Affect The Host Epigenome. Computational and Structural Biotechnology Journal. 2022, 20: 2455–2463 (IF2021=6.018)

4. Jing Tang#, Yongheng Wang#, Jianbo Fu#, Xianglu Wu, Zhijie Han, Chuan Wang, Maiyuan Guo, Yingxiong Wang,Yubin Ding*, Bo Yang*, Feng Zhu*. Functional characterization of disease/comorbidity-associated lncRNA. Quant. Biol. 2021: 9 (4): 411-425. doi: 10.15302/J-QB-021-0247

5. Armin Czika, Yin Yang, Jun-Pu Yang, Enoch Appiah Adu-Gyamfi, Amin Ullah, Ling-Ling Ruan, Xue-Mei Chen, Ying-Xiong Wang*, Mei-Jiao Wang*,Yu-Bin Ding*.A decrease in CD2 expression on NK cells is associated with PCOS but not influenced by metformin in a mouse model. Biol Reprod. 2022 Jan 29:ioac004. doi: 10.1093/biolre/ioac004. (IF2020=4.161)

6. Jones Lamptey, Armin Czika, John Ogooluwa Aremu, Sadaf Pervaz, Enoch Appiah Adu-Gyamfi, Antonia Otoo, Fangfang Li, Ying-Xiong Wang*,Yu-Bin Ding*. The role of fascin in carcinogenesis and embryo implantation. Exp Cell Res. 2021 Oct 15;409(1):112885(IF2022=4.145)

7. Enoch Appiah Adu-Gyamfi, Jones Lamptey, Xue-Mei Chen, Fang-Fang Li, Cong Li, Ling-Ling Ruan, Xue-Niu Yang, Tai-Hang Liu*, Ying-Xiong Wang*,Yu-Bin Ding*. Iodothyronine deiodinase 2 (DiO2) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage. Placenta. 2021 Aug;111: 54-68. doi: 10.1016/j.placenta.2021.06.004.(IF2020=3.481)

8. Lamptey J, Li F*, Adu-Gyamfi EA, Chen XM, Czika A, Otoo A, Liu TH, Wang YX*,Ding YB*. Downregulation of fascin in the first trimester placental villi is associated with early recurrent miscarriage. Exp Cell Res. 2021 Jun 1;403(1):112597. doi: 10.1016/j.yexcr.2021.112597.(IF2020=3.905)

9. Duan FM#, Fu Li-Juan#, Wang YH, Adu-Gyamfi EA, Ruan LL, Xu ZW, Xiao SQ, Chen XM, Wang, YX, Liu TH*,Ding YB*.THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia. Genes and Diseases. 2021,8(3): 353-363. DOI: 10.1016/j.gendis.2020.05.007(IF2020=7.103)

10. Hong-Lan Song#, Tai-Hang Liu#, Yong-Heng Wang, Fang-Fang Li, Ling-Ling Ruan, Enoch Appiah Adu-Gyamfi, Si-Chen Hu, Xue-Mei Chen,Yu-Bin Ding(导师), Li-Juan Fu*. Appropriate expression of P57kip2 drives trophoblast fusion via cell cycle arrest. Reproduction. 2021 May 5;161(6):633-644. doi: 10.1530/REP-20-0638. (IF2020=3.905)

11. Ding-Yuan Liu#, Ren-Yan Li#, Li-Juan Fu, Enoch Appiah Adu-Gyamfi, Yin Yang, Ying Xu, Le-Tian Zhao, Tian-Feng Zhang, Hua-Qiong Bao, Xiao-Ou Xu, Xiao-Han Gao, Xue-Niu Yang*,Yu-Bin Ding*.SNP rs12794714 of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case-control study.Arch of OB&GY. 2021 Jul;304(1):179-190.DOI: 10.1007/s00404-021-06004-y(IF2020=2.32)

12. Tang J#, Wu X#, Mou M, Wang C, Wang L, Li F,Guo M, Yin J, Xie W, Wang X, Wang Y,DingY*, Xue W* and Zhu F*. GIMICA: host genetic and immune factors shaping human microbiota. Nucleic Acids Res. 2021 Jan 8;49(D1): D715-D722. doi: 10.1093/nar/gkaa851.(IF2021=16.971)

13. Adu-Gyamfi EA, Czika A, Liu TH, Gorleku PN, Fondjo LA, Djankpa FT,Ding YB*, Wang YX*. Ephrin and Eph Receptor Signaling in Female Reproductive Physiology and Pathology. Biology of Reproduction, 2021 Jan 4;104(1):71-82. doi. 10.1093/biolre/ioaa171(IF2020=4.285)

14. Adu-Gyamfi E A, Djankpa FT, Nelson W, Czika A, Sah SK, Lamptey J,Ding YB*, Wang YX*. Activin and inhibin signaling: From regulation of physiology to involvement in the pathology of the female reproductive system. Cytokine.2020Sep;133:155105.doi: 10.1016/j.cyto.2020.155105. (IF2020=3.861)

15. Nelson W, Adu-Gyamfi EA, Czika A, Wang YX, Ding YB. Bisphenol A-induced mechanistic impairment of decidualization. Mol Reprod Dev. 2020 Aug;87(8):837-842.. doi: 10.1002/mrd.23400.(IF2020=2.609)

16. Nelson W, Wang YX, Sakwari G,Ding YB*. Review of the effects of perinatal exposure to EDCs in animals and humans. Reviews of Environmental Contamination and Toxicology.2020; 251:131-184. DOI 10.1007/398_2019_30(IF2020=7.56)

主持的科研项目

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